Dr Atul Gupta
MD (Res), CCT, MRCPCH, DNB, MD, MBBS,
Consultant in Paediatric Respiratory Medicine, King’s College Hospital,
Senior Lecturer, King’s College London, School of Medicine
Name: Atul Gupta
GMC Number: 6033985
HAAD Licence Holder
College/University Qualifications Date obtained
Imperial College, London MD, (Research) 2014
Certificate of Completion of
Medical Education and
Training Board, UK
Dual Accreditation in
Royal College of Paediatrics
and Child Health
National Board of
Examination, New Delhi, India
DNB Paediatrics 2000
Lady Hardinge Medical
College, University of Delhi,
New Delhi, India
MD Paediatrics 2000
Maulana Azad Medical
College, University of Delhi,
New Delhi, India
2015: £30000 to fund salary of the Darzi Fellow
2014: £12000 Education Fund / Award by Health Education England (HEE)
2012: Lorber Prize by Royal College of Paediatrics and Child Health (RCPCH)
2010: Asthma UK travel fellowship
2009: (£40850) The James fellowship, awarded by British Medical Association (BMA)
2009: BPRS fellowship for RCPCH, Spring Meeting
2008: BPRS travel fellowship for Congress for International Pediatric Pulmonology
2007: British Lung foundation travel fellowship for ERS Annual congress.
2000: S.S. Manchanda Neonatology Research Gold Medal-1999-2000 for the best
research work in neonatology conferred by the Indian Academy Of Pediatrics, India,
at its 37 National Conference ‘Pedicon 2000’ at Hyderabad, India.
2002: Awarded Co-sponsorship for Royal College of Paediatrics and Child Health,
Training Scheme for my performance during Post Graduate Residency at KSCH,
LHMC New Delhi, India.
2000: Ved & Sita Ram Memorial Gold Medal-1999-2000 for the best doctor in
Neonatology for the year 1999-2000, at Lady Hardinge Medical College & Associated
Kalawati Saran Children Hospital, New Delhi, India
Detailed practising history:
Senior Lecturer in Paediatric Respiratory Medicine King’s College
Consultant in Paediatric Respiratory Medicine King’s College
Senior Clinical Research Fellow
Research project on vitamin D and severe therapy
resistant asthma in children under supervision of Prof Andy
Bush & Dr Saglani at National Heart and Lung Institute
(NHLI), Imperial College, Royal Brompton Hospital and
Prof C Hawrylowicz at MRC & Asthma UK Centre in
Allergic Mechanisms of Asthma, Guy’s Hospital, King’s
College (KCL) London.
MRC & Asthma
UK Centre in
SpR: Paediatric Respiratory Medicine Great Ormond
SpR: Paediatric Intensive Care Unit (PICU)
Honorary Research Fellow : Paediatric Respiratory
SpR: Paediatric Respiratory Medicine Royal
SpR: Paediatric Immunology/ Allergy & Infectious
SpR: Paediatric Respiratory-Cardiology
SpR: Neonatal Paediatrics
SpR: General and Community QE, Hospital,
SpR (clinical fellow):Paediatric Intensive Care Unit
Yorkshire / Leeds SHO rotation: Neonatal Medicine,
Paed Neurology/Cardiology, General Paediatrics/
SHO: Neonatal Intensive Care/ General Paediatrics Queens Park
Medical officer: Public health, DOTS Project World Health
Organization (WHO) Delhi, India
Registrar: General Paediatrics/ PICU/ Paed A & E/ Paed
Paediatric SHO Rotation:
During this period, I also conducted an 18-month
prospective study on the efficacy and complications of
Fibreoptic Phototherapy and assessment of relationship of
Bilirubin with free oxygen radicals under the supervision of
Professor Arvind Saili & Professor R.P. Gupta, as part of my
dissertation for MD.
SHO: Orthopaedics Apollo
SHO: Radiology & Cardio thoracic surgery GB Pant H,
Management and Leadership:
• Clinical Lead for Asthma
• Asthma CQUIN / LIS for 2014-15 and 2015-16 against local and national
• Conference Director for two very successful (Inaugural and 2nd) King’s
Paediatric Respiratory International Conference at King’s College Hospital
• Member of Global Steering committee on Bright Start Foundation (UAE) for
maternal and child health
• Member of multiple international committee
• Established Paediatric Sleep Services at King’s College Hospital
• Development of Paediatric Respiratory Services
• International expert in Asthma
• Imperial / Brompton Management course (2007-9)
Vitamin D and Severe Therapy Resistant Asthma:
For the last seven years, I have been working on the relationship of vitamin D to
asthma severity and airway pathology and inflammation. I was awarded the “James
Trust Fellowship – BMA” (2009) to part-fund research costs. I was also awarded
Lorber Prize by Royal College of Paediatrics and Child Health (RCPCH). This work
has resulted in following peer reviewed publications:-
1. *Gupta A, *Dimeloe D, Richards DF, Chambers E, Black C, Urry Z, Ryanna K,
Xystrakis E, Bush A, Saglani S, Hawrylowicz CM. Aberrant IL-10 expression and
in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma.
Children with moderate and severe therapy resistant asthma are characterised
immunologically by defective anti-inflammatory interleukin (IL)-10 expression; in vitro,
steroids drive IL-10 expression, but also IL-17A, particularly in asthmatics. However,
active vitamin D potentiates steroid-induced IL-10 but not IL-17A and systemic vitamin
D status predicts airway IL-10 levels.
2. Gupta A, Dimeloe S, Richards D, Bush A, Saglani S, Hawrylowicz C. Vitamin D
binding protein and asthma severity in children. J Allergy Clin Immunol
In this cross-sectional study, we reported that bronchoalveolar lavage (BAL), but not
serum, levels of VDBP are significantly higher in STRA and that BAL VDBP levels
inversely correlate with asthma severity, as assessed by the asthma control test,
spirometry, and inhaled corticosteroids usage. These data highlight the potential
importance of the vitamin D axis, beyond vitamin D itself, in children with asthma.
3. Gupta A, Bush A, Hawrylowicz C, Saglani S. Vitamin D and Asthma in children.
Paediatr Respir Rev 2012;13(4): 236-43.
This review summarises the current understanding and uncertainties regarding the effect
of vitamin D deficiency and insufficiency in children with asthma.
4. Dimeloe S, Richards DF, Urry Z, Gupta A, Stratigou V, Farooque S, Saglani S,
Bush A, Hawrylowicz CM. 1α,25-Dihydroxyvitamin D3 Promotes CD200
Expression by Human Peripheral and Airway-Resident T Cells. Thorax
The induction of CD200, an immunoregulatory molecule, on human peripheral and
airway T cells is a novel mechanism whereby 1α25- dihydroxyvitamin D3 may act to
dampen down inflammation in the airway and maintain respiratory health
5. Urry Z, Xystrakis E, Dimeloe S, Richards D, Gabryšov L, Christensen J, Gupta A,
Saglani S, Bush A, O’Garra A, Brown Z and Hawrylowicz C. 1,25-
dihydroxyvitamin D3 promotes distinct Foxp3 and IL-10 expression by CD4+ T
cells. Eur J Immunol 2012;42 (10) :2697–2708.
We reported that 1,25-dihydroxyvitamin D3 enhances the frequency of both IL-10+ and
Foxp3+ T regulatory cells. In a translational setting, these data suggest that 1,25-
dihydroxyvitamin D3, over a broad concentration range, will be effective in enhancing
the frequency of T regulatory cells.
6. Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, Saglani S.
Relationship Between Serum Vitamin D, Disease Severity and Airway
Remodelling in Children with Asthma. Am J Respir Crit Care Med 2011;184:
We reported that the children with severe therapy resistant asthma (STRA) have lower
serum vitamin D levels compared with children with moderate asthma and control
subjects. Reduced vitamin D levels in STRA are associated with lower lung function,
poor asthma control, increased medication use, and asthma exacerbations. The serum
vitamin D level is inversely associated with airway smooth muscle mass.
7. Gupta Atul, Hawrylowicz C, Richards D, Bush A, Saglani S. Glucocorticosteroids
Are Potential Confounders in Studies of Vitamin D and Asthma. Am J Respir Crit
Care M 2012;185:1245-1246
8. Pfeffer P, Chen Y, Woszczek, G, Matthews NC, Chevretton E, Gupta A, Saglani
S, Bush A, Corrigan C, Cousins D, Hawrylowicz CM Vitamin D enhances
production of soluble ST2, inhibiting the action of IL-33. J Allergy Clin Immunol
2014 (in press, accepted for publication)
Vitamin D enhances production of sST2, the soluble decoy receptor for pro-inflammatory
IL – 33 . This likely contributes to the association between vitamin D sufficiency and
improved asthma control.
9. Rice L, Dimeloe S, Raynes J, Gupta A et al A Novel Immunomodulatory
Mechanism Mediated by Vitamin D, Alpha-1-antitrypsin and C3a of Relevance in
Airway Disease (under review, Thorax)
We reported that the vitamin D induces α-1-antitrypsin synthesis by CD4 T cells, which
interacts with C3a to mediate IL-10 synthesis. This is a novel mechanism of inflammatory
regulation, relevant in an array of inflammatory airway diseases including asthma, α-1-
antitrypsin deficiency and usual COPD and suggests novel translational approaches to
Additional Peer Reviewed Publications:
10. Brodlie M, Gupta A, Rodriguez-Martinez CE, Castro-Rodriguez JA, Ducharme
FM, McKean MC. Leukotriene receptor antagonists as maintenance or
intermittent treatment in pre-school children with episodic viral wheeze. Paediatr
Respir Rev. 2016 Jan;17:57-9. doi: 10.1016/j.prrv.2015.10.007.
11. Koo S, Gupta A, Fainardi V, Bossley C, Bush A, Saglani S, Fleming L. Ethnic
Variation in Response to IM Triamcinolone in Children With Severe Therapy-
Resistant Asthma. Chest. 2016 Jan;149(1):98-105. doi: 10.1378/chest.14-3241.
12. Brodlie M, Gupta A, Rodriguez-Martinez CE, Castro-Rodriguez JA, Ducharme
FM, McKean MC. Leukotriene receptor antagonists as maintenance and
intermittent therapy for episodic viral wheeze in children. Cochrane Database
Syst Rev. 2015 Oct 19; 10:CD008202. doi: 10.1002/14651858.CD008202.pub2.
13. Howard J, Inusa B, Liossi C, Jacob E, Murphy PB, Hart N, Gavlak J, Sahota S,
Chorozoglou M, Nwosu C, Gwam M, Gupta A, Rees DC, Thein SL, Reading IC,
Kirkham FJ, Cheng MY.Prevention of Morbidity in sickle cell disease–qualitative
outcomes, pain and quality of life in a randomised cross-over pilot trial of
overnight supplementary oxygen and auto-adjusting continuous positive airways
pressure (POMS2a). Trials. 2015 Aug 25;16:376.
14. Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley C, Buckley J, Ullmann
N, Grychtol R, Campbell G, · Bush A, Fleming L. Lloyd C, Saglani S, Pediatric
severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. J
Allergy Clin Immunol 03/2015; 129(2). DOI:10.1016/j.jaci.2015.01.016
15. Gielen V, Sykes A, Zhu J, Chan B, Regamey N, Kieninger E, Gupta A,
ShemarkA, Bossley C, Davies J, Saglani S, Walker, Nicholson S, Bush A,
Johnston S, Edwards MR. Increased nuclear suppressor of cytokine signaling 1
in asthmatic bronchial epithelium suppresses rhinovirus induction of innate
interferons. J Allergy Clin Immunol 01/2015; 179(1).
16. Kobayashi Y, Bossley C, Gupta A, Akashi K, Tsartsali L, Mercado N, Barnes, P,
Bush A, Ito K. Passive smoking impairs histone deacetylase-2 in children with
severe asthma. Chest 2014;145(2):305-312
17. Edwards M R, Regamey N, Vareille M, Kieninger E, Gupta A, Shoemark A,
Saglani S, Skyes S, Davies J, Bossley C, Bush A, Johnston SL. Impaired innate
interferon induction in severe therapy resistant atopic asthmatic children Mucosal
18. Bossley CJ, Fleming J, Gupta A, Regamey N, Frith J, Oates T, Tsartsali L, Lloyd
CM, Bush A, Saglani S. Pediatric severe asthma is characterized by eosinophilia
and remodeling without T(H)2 Cytokines. J Allergy Clin Immunol
19. Sharples J, Gupta A, Fleming L, Bossley C, Bracken-King M, Hall P, Hayward A,
Puckey M, Balfour-Lynn IM, Rosenthal M, Bush A, Saglani S. Long-term
effectiveness of a staged assessment for paediatric problematic severe asthma.
Eur Res J 2012;40(1):264–267
20. Gupta A, Cheetham T, Jaffray C, Ullman D, Gibb I, Spencer D. Repeatability of
the low-dose ACTH test in asthmatic children on inhaled corticosteroids. Acta
21. Gupta A, Khaw FM, Stokle EL, George RC, Pebody R, Stansfield RE, Spencer
DA. Outbreak of Streptococcus pneumoniae serotype 1 pneumonia in a United
Kingdom school. BMJ. 2009;338:950-2
22. Gupta A, Eastham KM, Wrightson N, Spencer DA. Hypomagnesaemia in cystic
fibrosis patients referred for lung transplant assessment. J Cyst
23. Dubey NK, Dey PK, Saxena S, Batra S, Khapekar P, Gupta A. Serum nitrite and
urinary nitrite excretion in nephrotic syndrome. Indian Pediatr. 2001;38(9):1025-9.
24. Marsh R, Gupta A, Gilhirst F, Hogg C, Lenney W, Bush A. The trachea with an
air-fluid level: a rare and bizarre radiological sign. Pediatr Pulmonol
25. Gupta A, Jamieson K, Bush A. A run too far. Pediatr Pulmonol. 2012;47(7):927-
26. Collins N, Gupta A, Wright S, Gauld L, Urquhart D, Bush A. Survey of the use of
non-invasive positive pressure ventilation in UK and Australasian children with
cystic fibrosis. Thorax. 2011;66:532-539
27. Gupta A, Marsh R, Jordan S, Padley S, Aboualfa K, Ola S, Fisher C, Nicholson
A, Bush A Endobronchial fibrosarcoma presenting as recurrent left sided
pneumonia. Pediatr Pulmonol 2011 Jun;46(6):610-3.
28. James C, Gupta A, Cheng D, Padley S, Goulden N, Skellett S. A boy frightened
of going to bed and bumps in the night. BMJ. 2009 July25; 339: 245.
29. Gupta A, Urquhart DS, Devaraj A, Balfour-Lynn IM. A 2 year old with fever and
cough. BMJ. 2009 July 11;339:113.
30. Gupta A. Scotland’s smoking ban means fewer kids in hospital with asthma.
Lung alert. Thorax. 2011;66:739
31. Gupta A, McKean M, Haynes S, Wright C, Barge D, Flood TJ, et al. Chronic
granulomatous disease presenting as fulminant Aspergillus pneumonitis: a lethal
combination? Pediatr Crit Care Med. 2009;10(4):43-5.
32. Gupta A, Urquhart D, Rosenthal M. Marked improvement in cystic fibrosis lung
disease and nutrition following change in home environment. J R Soc Med.
33. Gupta A, Marrs T, Urquhart D, Clarke S, Rosenthal M, Bush A. Fungal pleural
effusion secondary to a rare cause of pancreatic pseudocyst. Pediatr Pulmonol.
34. Gupta A, Magee A, Rosenthal M. Differential hyperaemia of the airways. Cardiol
35. Murdoch AM, Thia LP, Gupta A, Hogg CL. Recurrent chest infection in a 5 year
old boy. BMJ. 2009 May 9;338:1151.
36. Gupta A, Urquhart DS, Donovan S, Bush A. A 4 year old boy with recurrent
wheeze and chest infections. BMJ. 2009 May 2; 338:1085.
37. Gupta A, Pauliah S, Urquhart DS, Rosenthal M. Endobronchial polyp secondary
to pulmonary tuberculosis. Arch Dis Child. 2009 Mar;94(3):230.
38. Urquhart DS, Perry L, Gupta A, Rosenthal M. Sleep disordered breathing in a 4
year old child with Down’s syndrome. BMJ. 2008; Oct 1;337:823
39. Hodgkinson R, Urquhart DS, Thia L, Padley S, Bush A, Gupta A. An 11 month
old girl with bilateral wrist swelling. BMJ. 2008; Nov 5:1119
40. Gupta A, McKean M, Chang A. Management of chronic non-specific cough in
childhood: an evidence based review. Archives Dis Child Educ Pract Ed 2007
41. Gupta A. A view from the other side of the table. Arch Dis Child. 2007;92(4):372.
42. Gupta A, Saili A; Serial Serum C-Reactive Protein levels in the Diagnosis of
Neonatal Infections. Bulletin of Neonatology 1999;13(2) Vol 13, 64
43. Carter M, Gupta A. Managing the rise in pertussis GP national
newspaper. October 2012
44. Gupta A and Barnett M. Managing asthma in children GP national newspaper.
45. Gupta A, Bush A. Wheezing disorder in preschool children. GP national
newspaper. May 2009
46. Gupta A, Bush A. Asthma in children. GP national newspaper. Nov 2008
47. Gupta A, Bush A. Acute Cough in children.GP national newspaper.Nov 2008
48. Gupta A, Bush A Chronic Cough in children.GP national newspaper.Dec’08
49. Gupta A. Being on an interview panel. BMJ Careers.14 july 2000
Current Clinical Research:
I am the Chief Investigator (CI) of randomised, double-blind, placebo-controlled, parallelgroup
trial to evaluate efficacy and safety of Tiotropium delieved via Respimat inhaler once
daily over 48 weeks in children aged 6-11 years
Mepolizimab (Anti-IL5) study
I am the Principal Investigator Investigator (PI) of this clinical trial in children with severe
eosinophilic asthma over 64 weeks in children aged 6-11 years
I am Principal Investigator (PI) for STOP (suicidality treatment occurring in Paediatrics) Study.
There is insufficient data available about safety of using many medications (for example
Montelukast) in children and adolescents who may have an illness that itself predispose them
to suicidality. The STOP study aims to develop a comprehensive web-based methodology for
the assessment and monitoring of suicidality in children and adolescents.
Children’s Interstitial Lung Disease (ChILD-EU study)
I am Principal Investigator (PI) for FP7 study of Children’s Interstitial Lung Disease (ChILDEU
study) The research is pan-European and for 3.5 years. ChILD are a group of rare
diseases of the lung: most conditions have a poor outcome. There are too few cases in each
country to enable adequate research. The ChILD-EU project, funded by the European
Commission, is bringing together clinicians and child cases from across Europe.
Prevention of Morbidity in Sickle Cell Disease Phase 2b
I am co- Investigator for this research study
Respiratory and Sleep problems in children with sickle cell Anaemia